EasyNEET 2026
+4 / -1
Which one of the following disorders is caused by the substitution of Glutamic acid (Glu) by Valine (Val) at the sixth position of the β-globin chain of haemoglobin molecule?
A
Phenylketonuria
B
Haemophilia
C
Sickle-cell anaemia
D
Thalassaemia
Explanation
Sickle-cell anaemia is caused by a point mutation in the β-globin gene, resulting in the replacement of glutamic acid by valine at the sixth position of the β-globin chain.
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